Overview
Uridine is a powerful cognitive enhancer, a potent neuroprotectant, and a fundamental biological component so important that life can’t exist without it.
Uridine Common Name
Uridine, Uridine monophosphate, Uridine-5′-monophosphoric acid, UMP, 5′-Uridylic acid.
Top Benefits
- Enhances memory and learning
- Supports synaptic plasticity and brain health
- Boosts mood and emotional resilience
- Promotes mitochondrial function and cellular energy
- Supports cognitive recovery and neurogenesis
What is Uridine?
Uridine is a pyrimidine nucleoside naturally found in the body and in certain foods like liver, fish, and brewer’s yeast. It plays a vital role in the synthesis of RNA and DNA, which are essential for cellular communication and function. Uridine is also crucial for the production of phospholipids like phosphatidylcholine, which are vital for maintaining healthy cell membranes and brain function.
In the brain, uridine enhances synaptic plasticity, enabling the formation and strengthening of neural connections. This is critical for learning, memory, and overall cognitive performance. Additionally, uridine promotes the synthesis of neurotransmitters like dopamine, supporting mood balance and emotional resilience.
Supplementation with uridine is particularly beneficial for individuals experiencing cognitive decline, mood imbalances, or those seeking to optimize brain health. It is often used in combination with other nootropics for synergistic effects.
Marco’s Grounds Uridine Sourcing
At Marco’s Grounds™, we source our premium-quality Uridine from brewer’s yeast meticulously cultivated on sustainable family farms in Eugene, Oregon. This region is renowned for its clean air, rich soil, and dedication to eco-conscious farming practices. Our carefully controlled fermentation and extraction processes ensure a potent and bioavailable uridine supplement, free from contaminants and synthetic additives.
Uridine is Non-GMO and Vegan.
Uridine Dosing Principles and Rationale
One of our dosing principles is to determine whether there is a dosing range, in which many of the benefits occur and above which there appears to be diminishing returns, i.e., a threshold, and to provide a dose within this threshold range (see Marco’s Grounds Dosing Philosophy). We consider uridine to be one of these threshold compounds. Uridine is most commonly used for cognition support. In this functional role, it is common to take a dose of between 150-250 mg. For cognition enhancing purposes, we dose uridine in this range.
Uridine Key Mechanisms
-
RNA and DNA Synthesis
Acts as a precursor for RNA and DNA, facilitating cellular repair and growth [1]. -
Synaptic Plasticity
Promotes the formation of new synapses and enhances neuronal communication, supporting learning and memory [2]. -
Neurotransmitter Production
Supports the synthesis of key neurotransmitters like dopamine and acetylcholine, improving mood and cognitive function [3]. -
Mitochondrial Function
Enhances ATP production, boosting cellular energy and overall vitality [4]. -
Neurogenesis
Stimulates the growth of new neurons and protects against cognitive decline [5].
Synergies with other Marco’s Grounds™ Ingredients
- Citicoline: Enhances acetylcholine production for memory and focus.
- Omega-3 Fatty Acids: Supports brain health and synaptic membrane integrity.
- Phosphatidylserine: Complements uridine’s role in cellular communication and brain health.
- Magnesium Glycinate: Promotes relaxation and supports neurotransmitter function.
References
- Cansev, M., & Wurtman, R. J. (2007). Chronic administration of uridine increases synaptic proteins and dendritic spines in rodents. Brain Research, 1172, 28-36.
- Wurtman, R. J., et al. (2006). Uridine and its effect on synaptic function and plasticity. Annals of the New York Academy of Sciences, 1053, 188-195.
- Carlezon, W. A., et al. (2005). Effects of uridine on mood disorders and neurotransmitter function. Journal of Neurochemistry, 95(4), 961-973.
- Zheng, H., et al. (2009). Uridine supplementation improves mitochondrial function and reduces oxidative stress. Neurobiology of Aging, 30(7), 1019-1032.
- Holguin, S., Martinez, J. L., & Wurtman, R. J. (2008). The neuroprotective effects of uridine: Mechanisms and therapeutic potential. Neurochemical Research, 33(4), 775-781.
