Citicoline

Citicoline

Overview

Citicoline is a compound made up of choline and cytidine with neuroprotective as well as cognition increasing effects. Citicoline decreases age-related memory impairment and cognitive decline, and enhances attention, learning and memory.

 

Other Common Names

CDP-choline, Cytidine Diphosphocholine

 

Citicoline Key Mechanisms

After ingestion, CDP-choline originates choline and cytidine, the latter then being converted into uridine [1]

Both choline and uridine are neuroprotective [1]

Choline is a nicotinic acetylcholine receptor agonist [2]

Increases the production of acetylcholine, adrenalin and noradrenalin [1]

Increases the release of dopamine by acting on dopamine transporters [3]

Increases phosphatidylcholine production in the brain – an important component of cell membranes [4]

Maintains neuronal membrane integrity and reduces neuronal death [4, 5]

 

Citicoline Deep Dive

Marco’s Grounds Blog

Examine.com

 

References

  1. Weiss, G. B. (1995). Metabolism and actions of cdpcholine as an endogenous compound and administered exogenously as citicoline. Life sciences, 56(9), 637-660.
  2. Levin, E. D. (2013). Complex relationships of nicotinic receptor actions and cognitive functions. Biochemical pharmacology, 86(8), 1145-1152.
  3. Khosrow Tayebati, S., Tomassoni, D., Ejike Nwankwo, I., Di Stefano, A., Sozio, P., Serafina Cerasa, L., & Amenta, F. (2013). Modulation of monoaminergic transporters by choline-containing phospholipids. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 12(1), 94-103.
  4. Fagone, P., & Jackowski, S. (2013). Phosphatidylcholine and the CDP–choline cycle. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1831(3), 523-532.
  5. Dempsey, R. J., & Rao, V. L. R. (2003). Cytidinediphosphocholine treatment to decrease traumatic brain injury—induced hippocampal neuronal death, cortical contusion volume, and neurological dysfunction. Journal of neurosurgery, 98(4), 867-873.

Older post Newer post