Phosphatidylserine

Overview

Phosphatidylserine (PS) is a naturally occurring phospholipid crucial for maintaining cellular function, particularly in the brain. Widely recognized for its cognitive-enhancing and neuroprotective properties, PS supports memory, focus, and mental clarity while also aiding in stress management and physical recovery. As a key component of cell membranes, PS plays a vital role in maintaining brain health and function, making it a cornerstone of modern cognitive wellness.

Other Common Names

PS, Serine Phospholipid, Phospholipid PS

Top Benefits

• Enhances memory and cognitive function
• Supports stress resilience and emotional balance
• Promotes healthy brain aging
• Improves mental focus and clarity
• Aids physical recovery and athletic performance

What Is Phosphatidylserine?

Phosphatidylserine is a phospholipid found in high concentrations in the brain, where it facilitates communication between neurons, supports cellular repair, and enhances synaptic function. It is essential for maintaining the structural integrity and fluidity of cell membranes, which are critical for brain plasticity and cognitive performance.

Naturally present in foods such as soy, fish, and white beans, PS levels tend to decline with age, potentially impacting memory, focus, and mood. Supplementation with PS has been shown to mitigate these effects, improving cognitive function, reducing cortisol levels, and enhancing stress resilience. Additionally, PS supports physical recovery by modulating stress hormones and promoting overall cellular health.

Marco’s Grounds™ Phosphatidylserine Sourcing

At Marco’s Grounds™, we source our Phosphatidylserine from a family-owned sunflower farm in the fertile region of Guangzhou, China, known for its rich soil and ideal growing conditions.

Phosphatidylserine is naturally extracted from sunflower seeds through a gentle, chemical-free process. This process ensures that the extract retains its full potency, without the use of harsh chemicals, maintaining its natural purity and effectiveness.

Dosing Principles and Rationale

Clinical studies suggest effective daily doses of PS range from 100 to 300 mg, depending on individual needs. Marco’s Grounds™ incorporates Phosphatidylserine into synergistic formulations at the optimal dose to support brain health, stress resilience, and physical performance.

For best results, PS supplements are recommended in the morning or early afternoon to align with peak cognitive activity.

Phosphatidylserine Key Mechanisms

Cognitive Function and Neuroprotection

• Enhances synaptic plasticity, promoting memory formation and recall [1].
• Protects neurons from oxidative damage, supporting long-term brain health [2].

Stress Management

• Reduces cortisol levels, enhancing resilience to mental and physical stress [3].
• Modulates the hypothalamic-pituitary-adrenal (HPA) axis for emotional balance [4].

Athletic Performance and Recovery

• Improves exercise endurance by reducing cortisol spikes during physical exertion [5].
• Accelerates recovery by supporting cellular repair and reducing inflammation [6].

Synergies with Other Marco’s Grounds™ Ingredients

• Omega-3 Fatty Acids: Enhances neuronal membrane fluidity and cognitive performance.
• Ginkgo Biloba: Improves cerebral blood flow, complementing PS’s cognitive benefits.
• L-Theanine: Reduces stress and promotes mental clarity when paired with PS.

References

1. Glade, M. J., & Smith, K. (2015). Phosphatidylserine and the human brain. Nutrition, 31(6), 781-786.
2. Kidd, P. M. (1999). A review of phosphatidylserine clinical trials in aging and Alzheimer's disease. Alternative Medicine Review, 4(3), 144-161.
3. Monteleone, P., et al. (1992). Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. European Journal of Clinical Pharmacology, 42(4), 385-388.
4. Benton, D., et al. (2001). The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. Nutritional Neuroscience, 4(3), 169-178.
5. Kingsley, M., et al. (2006). Effects of phosphatidylserine supplementation on exercise capacity, muscle soreness, and recovery in soccer players. Medicine & Science in Sports & Exercise, 38(5), 1077-1085.
6. Starks, M. A., et al. (2008). The effects of phosphatidylserine on endocrine response to moderate intensity exercise. Journal of the International Society of Sports Nutrition, 5(1), 11.