Methylated Vitamin B-6 (Pyridoxine)

Overview

Vitamin B6, also known as pyridoxine, is a water-soluble vitamin essential for numerous physiological functions, including neurotransmitter synthesis, cognitive performance, energy metabolism, and immune support. Crucially involved in brain function, Vitamin B6 enhances mental clarity, sharpens focus, regulates mood, and promotes cardiovascular health by influencing homocysteine levels and enzyme activity. It also supports physical and mental resilience, helping the body adapt effectively to stress and fatigue.

Other Common Names

• Pyridoxine
• Pyridoxal-5-Phosphate (P5P)
• Pyridoxamine

Top Benefits

• Supports neurotransmitter production for mood regulation and mental clarity
• Enhances cognitive function, focus, and mental energy
• Promotes cardiovascular health by regulating homocysteine levels
• Boosts immune system performance
• Improves energy metabolism, physical recovery, and resilience to stress

What Is Vitamin B6?

Vitamin B6 is a vital nutrient involved in over 100 enzymatic reactions within the body. Its active form, Pyridoxal-5-Phosphate (P5P), acts as a critical coenzyme, particularly in amino acid metabolism and neurotransmitter synthesis—enhancing cognitive performance, mental clarity, and emotional resilience.

By supporting serotonin, dopamine, and GABA synthesis, Vitamin B6 promotes mood stability, clearer thinking, and sustained focus. It aids in energy production, hemoglobin formation for efficient oxygen transport, and helps maintain cardiovascular health through homocysteine regulation.

Though found naturally in foods like poultry, fish, potatoes, and bananas, modern diets and lifestyles can lead to suboptimal Vitamin B6 levels, making targeted supplementation essential for peak physical and mental performance.

Marco’s Grounds™ Vitamin B6 Sourcing

At Marco’s Grounds™, our Vitamin B6 is sourced from poultry raised on family-owned farms in the nutrient-rich region of Waikato, New Zealand. These birds are naturally nourished on a balanced diet, allowing them to synthesize Vitamin B6 efficiently as part of their metabolic process.

Through a meticulous, nature-aligned extraction from these poultry sources, our Vitamin B6 is carefully refined to preserve its bioactive form. This ensures exceptional purity, potency, and absorption — delivering essential support for mood, metabolism, and cognitive function in every dose.

Dosing Principles and Rationale

Recommended daily intakes of Vitamin B6 range from 1.3 to 2 mg for most adults, while therapeutic doses typically span 10 to 50 mg per day. Marco’s Grounds™ employs optimally calibrated amounts of Pyridoxal-5-Phosphate, adhering to hormetic dosing principles to maximize benefits without overstimulation.

For comprehensive effects, Vitamin B6 is ideally combined with a full B-complex to create synergy across cognitive, metabolic, cardiovascular, and neurological pathways.

Vitamin B6 Key Mechanisms

1. Cognitive Performance & Mental Clarity

• Facilitates dopamine and serotonin synthesis, improving cognitive sharpness, clarity, and mental stamina [1].

• Supports GABA production, enhancing calm focus and reducing mental fatigue [2].
  

2. Neurotransmitter Production & Mood Regulation

• Enhances serotonin and dopamine pathways, regulating mood, emotional stability, and stress response [3].

• Supports melatonin synthesis, promoting restful sleep and mental recovery [4].

3. Cardiovascular Health & Stress Resilience

• Maintains optimal homocysteine levels, improving vascular function and physical resilience to stress [5].

• Synergistically interacts with folate and B12, supporting overall cardiovascular efficiency and reducing fatigue.

4. Energy Metabolism & Physical Recovery

• Acts as a critical coenzyme in carbohydrate, lipid, and amino acid metabolism, boosting physical energy and endurance [6].

• Supports red blood cell formation and efficient oxygen delivery, enhancing physical performance and recovery [7].

4. Energy Metabolism & Physical Recovery

• Enhances lymphocyte function and overall immune responsiveness, strengthening resilience against physical and mental stressors [8].

Synergies with Other Marco’s Grounds™ Ingredients

• L-Theanine: calm the mind and sharpen focus, supporting both relaxation and cognitive clarity in high-performance settings.

• Rhodiola Crenulata: enhance cognitive performance, neurotransmitter balance, and stress adaptation through complementary pathways.

• Magnesium Glycinate: complements B6 in neurotransmitter production and muscle relaxation.

References

1. Dakshinamurti, K., & Sharma, S. K. (1998). Neurochemical and behavioural aspects of pyridoxine deficiency. Nutrition Research Reviews, 11(1), 117–136.
2. Zempleni, J., et al. (2003). Biotin and B vitamins in health and disease. Annual Review of Nutrition, 23(1), 317–341.
3. Selhub, J. (1999). Homocysteine metabolism. Annual Review of Nutrition, 19(1), 217-246.
4. Merrill, A. H., & Henderson, J. M. (1987). Vitamin B6 metabolism by human liver. Annual Review of Nutrition, 7(1), 137-156.
5. Driskell, J. A. (1999). Vitamin B6 requirements for humans. Nutrition Research Reviews, 12(1), 65-86.
6. Rall, L. C., & Meydani, S. N. (1993). Vitamin B6 and immune competence. Nutrition Reviews, 51(7), 217–225.