Methylated Vitamin B-6 (Pyridoxine)

Overview

Vitamin B6, also known as pyridoxine, is a water-soluble vitamin essential for numerous physiological functions, including neurotransmitter synthesis, energy metabolism, and immune support. It plays a critical role in brain function, mood regulation, and cardiovascular health by influencing homocysteine levels and supporting optimal enzyme activity.

Other Common Names

• Pyridoxine
• Pyridoxal-5-Phosphate (P5P)
• Pyridoxamine

Top Benefits

• Supports neurotransmitter production for mood regulation
• Promotes cardiovascular health by regulating homocysteine levels
• Enhances energy metabolism and enzyme function
• Boosts immune system performance
• Supports cognitive function and mental clarity

What Is Vitamin B6?

Vitamin B6 is a vital nutrient required for over 100 enzymatic reactions in the body. Its active form, Pyridoxal-5-Phosphate (P5P), acts as a coenzyme in numerous metabolic pathways, particularly those involved in amino acid metabolism and neurotransmitter synthesis.

By supporting the production of serotonin, dopamine, and GABA, Vitamin B6 contributes to emotional stability, cognitive focus, and stress resilience. It also plays key roles in converting food into usable energy, forming hemoglobin for oxygen transport, and maintaining heart health through homocysteine regulation.

Although Vitamin B6 is found in foods like poultry, fish, potatoes, and bananas, deficiencies may arise due to poor diet, certain medications, or underlying health conditions — making supplementation a strategic choice for many.

Marco’s Grounds™ Vitamin B6 Sourcing

At Marco’s Grounds™, our Vitamin B6 is sourced from poultry raised on family-owned farms in the nutrient-rich region of Waikato, New Zealand. These birds are naturally nourished on a balanced diet, allowing them to synthesize Vitamin B6 efficiently as part of their metabolic process.

Through a meticulous, nature-aligned extraction from these poultry sources, our Vitamin B6 is carefully refined to preserve its bioactive form. This ensures exceptional purity, potency, and absorption — delivering essential support for mood, metabolism, and cognitive function in every dose.

Dosing Principles and Rationale

Recommended daily intakes for Vitamin B6 range from 1.3 to 2 mg for most adults, though therapeutic applications often call for doses between 10 and 50 mg per day. Marco’s Grounds™ uses optimally calibrated amounts of Pyridoxal-5-Phosphate, in line with hormetic dosing principles, to provide effective support without overloading the system.

For comprehensive results, Vitamin B6 is often paired with a full B-complex to promote synergy across neurological, metabolic, and cardiovascular pathways.

Vitamin B6 Key Mechanisms

1. Neurotransmitter Production & Mood Regulation

• Supports serotonin synthesis for mood and melatonin production for sleep [1]

• Facilitates dopamine and GABA synthesis for enhanced focus and relaxation [2]

2. Cardiovascular Health

• Regulates homocysteine levels, reducing cardiovascular risk [3]

• Works synergistically with folate and B12 to support vascular function

3. Energy Metabolism & Hemoglobin Formation

• Acts as a coenzyme in glucose, lipid, and amino acid metabolism [4]

• Supports red blood cell production and oxygen delivery via hemoglobin synthesis [5]

4. Immune System Support

• Enhances lymphocyte production and immune responsiveness [6]

Synergies with Other Marco’s Grounds™ Ingredients

• L-Theanine: calm the mind and sharpen focus, supporting both relaxation and cognitive clarity in high-performance settings.

• Rhodiola Crenulata: enhance cognitive performance, neurotransmitter balance, and stress adaptation through complementary pathways.

• Magnesium Glycinate: complements B6 in neurotransmitter production and muscle relaxation.

References

1. Dakshinamurti, K., & Sharma, S. K. (1998). Neurochemical and behavioural aspects of pyridoxine deficiency. Nutrition Research Reviews, 11(1), 117–136.
2. Zempleni, J., et al. (2003). Biotin and B vitamins in health and disease. Annual Review of Nutrition, 23(1), 317–341.
3. Selhub, J. (1999). Homocysteine metabolism. Annual Review of Nutrition, 19(1), 217-246.
4. Merrill, A. H., & Henderson, J. M. (1987). Vitamin B6 metabolism by human liver. Annual Review of Nutrition, 7(1), 137-156.
5. Driskell, J. A. (1999). Vitamin B6 requirements for humans. Nutrition Research Reviews, 12(1), 65-86.
6. Rall, L. C., & Meydani, S. N. (1993). Vitamin B6 and immune competence. Nutrition Reviews, 51(7), 217–225.