Melatonin

Overview

Melatonin is a naturally occurring hormone that regulates the body’s sleep-wake cycle, often referred to as the circadian rhythm. Known as the “sleep hormone,” melatonin plays a critical role in promoting restful sleep, supporting recovery, and enhancing overall well-being. Supplementation with melatonin has become a popular and effective solution for improving sleep quality, especially for individuals struggling with jet lag, shift work, or sleep disorders.

Other Common Name

N-acetyl-5-methoxytryptamine

Top Benefits

• Regulates the sleep-wake cycle
• Improves sleep quality and duration
• Supports recovery and cellular repair during sleep
• Reduces symptoms of jet lag
• Enhances immune system function

What Is Melatonin?

Melatonin is a hormone produced by the pineal gland in response to darkness. Its primary function is to signal the body that it is time to rest, making it a vital component of the sleep-wake cycle. Factors such as stress, blue light exposure, and irregular schedules can disrupt natural melatonin production, leading to poor sleep quality.

Melatonin supplementation can help restore balance by aligning the body’s circadian rhythm. Beyond sleep, melatonin exhibits powerful antioxidant properties, supporting cellular repair and immune function. It also aids in regulating mood and combating oxidative stress, making it a versatile addition to any wellness regimen.

Marco’s Grounds™ Melatonin Sourcing

At Marco’s Grounds™, we source our Melatonin from a family-owned farm specializing in St. John’s Wort, located in the pristine regions of Northern India. The farm’s commitment to sustainable practices ensures exceptional purity and potency in every batch.

Our Melatonin is carefully extracted from the St. John’s Wort plant, and is non-GMO, gluten-free, and adheres to the highest safety and quality standards. This dedication to excellence guarantees a premium product that supports restful sleep and overall well-being with every dose.

Dosing Principles and Rationale

Effective doses of melatonin range from 0.5 mg to 3 mg for most individuals, with higher doses used in specific clinical scenarios. Marco’s Grounds™ adheres to hormetic dosing principles, ensuring the optimal dose to enhance sleep quality while minimizing potential side effects.

Melatonin is best taken 30-60 minutes before bedtime to support natural sleep cycles. For managing jet lag, melatonin is most effective when taken close to the local bedtime at the destination.

Melatonin Key Mechanisms

Sleep Regulation

• Binds to melatonin receptors in the brain, signaling the onset of sleep [1].
• Synchronizes the body’s internal clock, improving sleep quality and duration [2].

Recovery and Cellular Repair

• Exhibits antioxidant properties, reducing oxidative damage during sleep [3].
• Promotes the repair of DNA and cellular structures [4].

Jet Lag and Circadian Rhythm Support

• Helps the body adjust to new time zones by resetting the internal clock [5].

Immune Support

• Enhances immune cell activity, supporting the body’s natural defenses [6].

Synergies with Other Marco’s Grounds™ Ingredients

• L-Theanine: Enhances relaxation and reduces stress, improving sleep onset.
• Magnesium Glycinate: Promotes muscle relaxation and enhances melatonin’s effects.
• Chamomile: Complements melatonin’s calming properties for restorative sleep.

References

1. Hardeland, R., et al. (2006). Melatonin and melatonergic drugs in clinical practice. Journal of Pineal Research, 41(3), 261-275.
2. Sack, R. L., et al. (2007). Circadian rhythm sleep disorders: Pathophysiology and treatment. Sleep, 30(11), 1460-1483.
3. Tan, D. X., et al. (2002). Melatonin as a potent and widespread antioxidant: Current evidence and clinical applications. Endocrine Reviews, 23(6), 719-753.
4. Reiter, R. J., et al. (2000). Melatonin reduces oxidant damage and promotes mitochondrial function. Biochemistry and Cell Biology, 78(5), 447-458.
5. Arendt, J. (2009). Managing jet lag: Some of the problems and possible new solutions. Sleep Medicine Reviews, 13(4), 249-256.
6. Carrillo-Vico, A., et al. (2005). Melatonin: Buffering the immune system. International Journal of Molecular Sciences, 6(4), 210-223.