Magnesium Glycinate

Overview

Magnesium Glycinate, renowned as the "relaxation mineral," is a highly absorbable form of magnesium that delivers profound calming effects to both mind and body. Essential in over 300 biochemical reactions, it uniquely supports stress reduction, deepens sleep quality, and promotes mental clarity. Combining magnesium with the soothing amino acid glycine, Magnesium Glycinate provides unparalleled tranquility, making it a cornerstone supplement for managing stress and enhancing overall well-being.

Other Common Names

Bisglycinate Magnesium
Magnesium Diglycinate

Top Benefits

Promotes relaxation and stress resilience
Supports deep, restorative sleep
Calms the mind and enhances mental clarity
Aids muscle relaxation and recovery
Improves cardiovascular and bone health

What Is Magnesium Glycinate?

Magnesium is an essential mineral involved in over 300 biochemical processes in the body, including energy production, nerve function, and muscle relaxation. Magnesium Glycinate combines magnesium with glycine, a non-essential amino acid known for its calming effects, creating a highly absorbable form of magnesium with added relaxation benefits.

This unique form of magnesium is especially effective for promoting mental calmness, improving sleep, and reducing stress. Unlike other magnesium supplements, Magnesium Glycinate is less likely to cause gastrointestinal discomfort, making it ideal for those with sensitive stomachs.

Deficiencies in magnesium are common due to modern diets and soil depletion, leading to symptoms such as fatigue, muscle cramps, and poor sleep. Supplementing with Magnesium Glycinate provides a reliable, well-tolerated solution to restore optimal levels and promote whole-body wellness.

Marco’s Grounds™ Magnesium Glycinate Sourcing

At Marco’s Grounds™, our Magnesium Glycinate is sourced with a relentless focus on purity, bioavailability, and sustainability. We extract magnesium from salmon raised in a family-owned fishpond in Norway, then chelate it with glycine—an amino acid known for its calming effects—to create an exceptionally absorbable and gentle form of magnesium.

Every batch is subjected to rigorous quality control, ensuring it remains free from heavy metals, GMOs, and synthetic additives. The result: clean, effective support for relaxation, recovery, and total-body resilience — delivered with uncompromising precision in every dose.

Magnesium Glycinate Dosing Principles and Rationale

Optimal dosing ranges between 200–400 mg of elemental magnesium daily, carefully calibrated according to hormetic dosing principles. This ensures maximum calming benefits without overwhelming the body.

For stress reduction, relaxation, and sleep support, Magnesium Glycinate is best consumed in the evening. To support muscle recovery and overall wellness, it can also be taken throughout the day with meals.

For relaxation and sleep support, Magnesium Glycinate is best taken in the evening.
For muscle recovery and general wellness, it can be taken with meals throughout the day.

Magnesium Glycinate Key Mechanisms

1. Relaxation and Stress Reduction

Increases GABAergic activity, calming the brain and reducing stress [1].
Regulates the HPA axis, moderating cortisol and stress responses [2].

2. Sleep Quality

Boosts melatonin synthesis and relaxes the nervous system for deeper rest [3].
Reduces nighttime muscle tension and restlessness, enhancing sleep recovery [4].

3. Muscle and Recovery

Balances calcium signaling to prevent cramps and aid muscular relaxation [5].
Supports ATP production and electrolyte balance for efficient recovery [6].

4. Cardiovascular and Bone Health

Relaxes vascular smooth muscle to maintain healthy blood pressure [7].
Improves bone mineral density through enhanced calcium utilization [8].

5. Cognitive Clarity and Emotional Stability

Stabilizes neurotransmitter balance, improving focus and emotional regulation [9].
Reduces mental fatigue and brain fog by optimizing neuronal energy metabolism [10].

Synergies with other Marco’s Grounds™ Ingredients

Vitamin B6 – Enhances magnesium absorption and its calming effects.
L-Theanine – Amplifies stress-relieving benefits and relaxation.
Ashwagandha – Works synergistically to enhance stress resilience and support overall calmness.

References

Eby, G. A., & Eby, K. L. (2006). Rapid recovery from major depression using magnesium treatment. Medical Hypotheses, 67(2), 362–370.
Boyle, N. B., Lawton, C., & Dye, L. (2017). Effects of magnesium supplementation on anxiety and stress. Nutrients, 9(5), 429.
Abbasi, B., et al. (2012). Magnesium supplementation for primary insomnia in the elderly. Journal of Research in Medical Sciences, 17(12), 1161.
Romero, J. R., & Sanderson, W. C. (2000). Magnesium in muscle function and recovery. American Journal of Therapeutics, 7(4), 267–273.
de Baaij, J. H., et al. (2015). Magnesium in man: Implications for health and disease. Physiological Reviews, 95(1), 1–46.
Wester, P. O. (1987). Magnesium in clinical nutrition. American Journal of Clinical Nutrition, 45(5), 1305–1312.
Houston, M. (2011). Magnesium and cardiovascular disease. Journal of Clinical Hypertension, 13(11), 843–847.
Rude, R. K., & Shils, M. E. (2006). Magnesium. In Modern Nutrition in Health and Disease (10th ed., pp. 223–247).
Barbagallo, M., & Dominguez, L. J. (2010). Magnesium and aging: Neuroprotection and cognitive function. Current Pharmaceutical Design, 16(7), 832–839.
Slutsky, I., et al. (2010). Enhancement of learning and memory by elevating brain magnesium. Neuron, 65(2), 165–177.