BioPerine® Black Pepper

Overview

BioPerine® is a patented extract of black pepper fruit (Piper nigrum) standardized to contain 95% piperine, a bioactive alkaloid known for dramatically enhancing nutrient absorption. It serves as a powerful bioavailability enhancer, amplifying the effectiveness of key vitamins, minerals, and herbal compounds by improving their uptake and utilization in the body.

Other Common Names

• Piperine
• Black Pepper Extract
• Piper nigrum Fruit Extract
  

Top Benefits

• Enhances absorption of calming nutrients
• Supports mood and stress balance
• Improves gut health and digestion
• Amplifies anti-inflammatory response
  

What Is BioPerine®?

BioPerine® is a standardized extract derived from the dried fruits of black pepper, prized for its high concentration of piperine, the compound responsible for black pepper’s pungency and absorption-boosting effects. Developed by Sabinsa Corporation, BioPerine® is the only piperine extract to have undergone extensive clinical studies demonstrating its ability to enhance the bioavailability of a wide range of nutrients, from curcumin to selenium.

Piperine works primarily by inhibiting enzymes that metabolize nutrients too quickly and by increasing thermogenesis (the body’s production of heat), which improves blood flow and intestinal absorption. This dual mechanism helps increase the efficacy of co-administered compounds, allowing lower doses to deliver greater results.

In performance and longevity supplementation, BioPerine® plays a crucial role in ensuring that critical nutrients like curcumin, ashwagandha, CoQ10, and fat-soluble vitamins are absorbed and utilized with maximum efficiency.

Marco’s Grounds™ BioPerine® Sourcing

At Marco’s Grounds™, our BioPerine® is sourced from organically grown black pepper cultivated on family-owned farms in the fertile, sun-drenched regions of Southern India. These ideal growing conditions naturally concentrate piperine, the active compound responsible for enhanced nutrient absorption.

We use only BioPerine®, the patented and clinically validated extract standardized to 95% piperine. Crafted through a solvent-free extraction process and verified by third-party testing, each batch ensures maximum purity, potency, and bioavailability, empowering the full impact of every formula we create.

BioPerine® Dosing Principles and Rationale

Effective dosing of BioPerine® ranges from 5 mg to 10 mg daily depending on the formulation. Clinical studies show that even low doses of piperine significantly improve the absorption of co-administered nutrients, particularly fat-soluble vitamins, polyphenols, and adaptogens.

Marco’s Grounds™ strategically incorporates BioPerine® at 5 mg per serving, an evidence-based dose shown to elevate the efficacy of powerful ingredients such as curcumin, ashwagandha, and vitamin K2 without overstimulating the digestive tract.

BioPerine® Key Mechanisms

1. Enhanced Nutrient Bioavailability

• Inhibits glucuronidation and digestive enzyme activity, extending the plasma residence time of nutrients and allowing for higher absorption [1].

2. Thermogenic Activation

• Stimulates thermogenesis, improving blood flow to the gastrointestinal tract and increasing nutrient transport across intestinal walls [2].

3. Improved Gut Absorption

• Modifies membrane dynamics in the intestinal lining, enhancing permeability for key compounds [3].

4. Anti-inflammatory and Antioxidant Support

• Suppresses pro-inflammatory cytokines and increases endogenous antioxidant enzyme activity [4].

5. Synergistic Amplification

• Significantly increases the bioefficacy of ingredients like curcumin, resveratrol, selenium, and CoQ10 [5].

Synergies with Other Marco’s Grounds™ Ingredients

• Ashwagandha – Enhances absorption and effectiveness of withanolides
• Vitamin K2 + D3 – Improves uptake of these fat-soluble vitamins for superior metabolic effect
  

References

1. Shoba, G., et al. (1998). Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, 64(4), 353–356.
2. Lambert, J. D., et al. (2004). Piperine enhances the bioavailability of the tea polyphenol epigallocatechin-3-gallate in mice. Journal of Nutrition, 134(8), 1948–1952.
3. Srinivasan, K. (2007). Black pepper and its pungent principle piperine: A review of diverse physiological effects. Critical Reviews in Food Science and Nutrition, 47(8), 735–748.
4. Mujumdar, A. M., et al. (1990). Anti-inflammatory activity of piperine. Planta Medica, 56(5), 515–516.
5. Badmaev, V., et al. (1999). Piperine, a bioavailability enhancer, in nutrient absorption. Nutrition Science News, 4(1), 1–5.