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HUPERZIA SERRATA LEAF

Huperzia-full-plant
THE GIST

OVERVIEW

Huperzine A is a potent natural synaptic enzyme modulator. Studies indicate its ability to support learning, memory, neuroplasticity, and executive function.

Extracted from the firmoss huperzia serrata, huperzine A is a naturally occurring alkaloid that quickly permeates the blood-brain barrier and restricts the action of acetylcholinesterase, the enzyme that breaks down acetylcholine. Huperzine A has been shown to have a high affinity for brain cholinesterases, establishing its reputation as a highly effective compound to increase acetylcholine levels without side effects. Several studies found that huperzine A reduced acetylcholinesterase activity by up to 20%.

SYNONYMS

OTHER COMMON NAMES

Huperzine A extracted  from the huperzia serrata leaf. 

IN A NUTSHELL

TOP BENEFITS

Supports learning

Supports memory

Supports neuroplasticity 

DEFINITION

WHAT IS HUPERZINE A?

Huperzine A is an extract found in many herbs known for memory and learning enhancing properties. The compound is primarily useful because it inhibits an enzyme in the brain that breaks down a brain chemical called acetylcholine. Thus, preventing the breakdown of this neurotransmitter, the natural result is more of this brain chemical in the brain.

Acetylcholine is considered the main brain chemical associated with memory formation and learning ability, which has downstream effects for treating Alzheimer’s disease [1]. While long-term research is missing, the evidence thus far is compellingly in favor of using huperzine A as a cholinergic compound.

HUPERZINE A ROLE IN OUR FORMULATION

FOCUS
33.3%
MEMORY
66.6%
CLARITY
100%
MOOD
66.6%

HUPERZINE A KEY MECHANISMS

Acetylcholinesterase inhibitor [2]

NMDA receptor antagonist [2]

Neuroprotective against hydrogen peroxide damage, glutamate excitotoxicity, and beta-amyloid pigmentation [ 2]

Neurogenic through the increased proliferation of hippocampal neural stem cells and NGF stimulation [3]

Upregulates REM sleep (many users report increased lucid dreaming)

Supports memory consolidation and neuroplasticity [2]

Synergistic with cholinomimetics and cholinosensitizers​​

HUPERZINE A DEEP DIVE

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MAXIMUM MIND®

Clinically Studied

Pharmaceutical Grade Cognitive and Mind Enhancing Complex
Made in Switzerland

References

  1. Wang, B. S., Wang, H., Wei, Z. H., Song, Y. Y., Zhang, L., & Chen, H. Z. (2009). Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer’s disease: an updated meta-analysis. Journal of neural transmission (Vienna, Austria: 1996), 116(4), 457–465.
  2. Wang, R., Yan, H., & TANG, X. C. (2006). Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine 1. Acta Pharmacologica Sinica, 27(1), 1-26.
  3. Ma, T., Gong, K., Yan, Y., Zhang, L., Tang, P., Zhang, X., & Gong, Y. (2013). Huperzine A promotes hippocampal neurogenesis in vitro and in vivo. Brain research, 1506, 35-43.